Number of the records: 1
In-Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers under Static and Dynamic Conditions
- 1.
SYSNO ASEP 0457461 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title In-Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers under Static and Dynamic Conditions Author(s) Tian, F. (US)
Min, J. (US)
Kaňka, Jiří (URE-Y)
Hammond, P. T. (US)
Du, H. (US)Source Title Proceedings of SPIE - FIBER OPTIC SENSORS AND APPLICATIONS XII, 9480. - Washington : SPIE, 2015 / Udd Erick ; Pickrell Gary ; Du H. Henry - ISSN 0277-786X - ISBN 978-1-62841-596-4 Pages s. 9480051-9480059 Number of pages 9 s. Publication form Print - P Action Conference on Fiber Optic Sensors and Applications XII Event date 22.04.2015 - 23.04.2015 VEvent location Baltimore Country US - United States Event type WRD Language eng - English Country US - United States Keywords long period grating ; drug release ; polyelectrolyte Subject RIV JA - Electronics ; Optoelectronics, Electrical Engineering R&D Projects LH11038 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support URE-Y - RVO:67985882 UT WOS 000357019100004 EID SCOPUS 84948823609 DOI 10.1117/12.2191683 Annotation The release profiles of gentamicin sulfate (GS) from [chitosan (CHI)/poly(acrylic acid) (PAA)/GS/PAA](n) polyelectrolyte multilayers were investigated in situ using an innovative lab-on-fiber (LOF) optofluidic platform that mimics physiologically relevant fluid flow in a microenvironment. The LOF was constructed by enclosing in a flow-enabled and optically coupled glass capillary a long-period fiber grating both as a substrate for LbL growth of [CHI/PAA/GS/PAA] n and a measurement probe for GS release. We show that the LOF is very robust in monitoring the construction of the [CHI/PAA/GS/PAA] n multilayers at monolayer resolution as well as evaluating the rate of GS release with high sensitivity. The release processes in the LOF under static and a range of dynamic conditions are evaluated, showing a faster release under dynamic condition than that under static condition due to the varying circumstance of GS concentration gradient and the effect of flow-induced shear at the medium-multilayer interface. The LOF platform has the potential to be a powerful test bed to facilitate the design and evaluation of drug-eluting polyelectrolyte thin films for their clinical insertion as part of patient care strategy Workplace Institute of Radio Engineering and Electronics Contact Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Year of Publishing 2016
Number of the records: 1