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Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers
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SYSNO ASEP 0457459 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers Author(s) Tian, F. (US)
Min, J. (US)
Kaňka, Jiří (URE-Y)
Li, X. (US)
Hammond, P. T. (US)
Du, H. (US)Source Title Optics Express. - : Optical Society of America - ISSN 1094-4087
Roč. 23, č. 15 (2015), s. 20132-20142Number of pages 11 s. Publication form Print - P Language eng - English Country US - United States Keywords long-period grating ; drug release ; thin film Subject RIV JA - Electronics ; Optoelectronics, Electrical Engineering R&D Projects LH11038 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support URE-Y - RVO:67985882 UT WOS 000361035300151 EID SCOPUS 84954473447 DOI 10.1364/OE.23.020132 Annotation A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA](n) multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 degrees C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Our findings underscore the importance of conducting drug release studies in physiologically relevant conditions Workplace Institute of Radio Engineering and Electronics Contact Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Year of Publishing 2016
Number of the records: 1