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Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents.
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SYSNO ASEP 0457446 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents. Author(s) Klučková, Katarína (BTO-N) RID
Dong, L. F. (AU)
Bajziková, Martina (BTO-N) RID
Rohlena, Jakub (BTO-N) RID, ORCID
Neužil, Jiří (BTO-N) RIDSource Title Methods in molecular biology - ISSN 1940-6029
Roč. 1265, 07 Oct 2015 (2015), s. 181-194Number of pages 14 s. Language eng - English Country US - United States Keywords Animals ; Antineoplastic Agents ; drug effects ; *pharmacology Subject RIV EB - Genetics ; Molecular Biology R&D Projects ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support BTO-N - RVO:86652036 DOI 10.1007/978-1-4939-2288-8_14 Annotation Respiration is one of the major functions of mitochondria, whereby these vital organelles use oxygen to produce energy. Many agents that may be of potential clinical relevance act by targeting mitochondria, where they may suppress mitochondrial respiration. It is therefore important to evaluate this process and understand how this is modulated by small molecules. Here, we describe the general methodology to assess respiration in cultured cells, followed by the evaluation of the effect of one anticancer agent targeted to mitochondria on this process, and also how to assess this in tumor tissue. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2016
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