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Synthesis and Comparative Study of Ammonium and Phosphonium Terminated Carbosilane Dendrimers.

SYSNO ASEP	0457374
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	The record was not marked in the RIV
Title	Synthesis and Comparative Study of Ammonium and Phosphonium Terminated Carbosilane Dendrimers.
Author(s)	Strašák, Tomáš (UCHP-M)_{RID, ORCID, SAI} Müllerová, Monika (UCHP-M)_{RID, ORCID, SAI} Čermák, Jan (UCHP-M)_{RID, ORCID, SAI} Malý, J. (CZ) Malý, M. (CZ) Wróbel, D. (CZ)
Source Title	Poster Communications Abstracts. - - : -, 2015 - ISBN N
Pages	s. 206
Number of pages	1 s.
Publication form	Online - E
Action	EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry /6./
Event date	15.11.2015 - 18.11.2015
VEvent location	Rehovot
Country	IL - Israel
Event type	WRD
Language	eng - English
Country	IL - Israel
Keywords	CB-DDM ; phosphorium ; ammonium
Subject RIV	CC - Organic Chemistry
Institutional support	UCHP-M - RVO:67985858
Annotation	Here we report synthesis of new library of CB-DDM with both ammonium and phosphonium groups on the periphery. To evaluate the effect of substitution of substitution of nitrogen atom by phosphorus we prepared two series of identical CS_DDM in 1st – 3rd generations which differs only in onium groups (N or P). Comparative study of their cytotoxicity, the ability to form dendriplexes and their transfections through cell membrane will be presented. The results are supported by computational modeling.
Workplace	Institute of Chemical Process Fundamentals
Contact	Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227
Year of Publishing	2016

Number of the records: 1