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Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting

SYSNO ASEP	0456084
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting
Author(s)	Chen, Y. (CN) Minh, L. V. (CN) Liu, J. (CN) Angelov, Borislav (UMCH-V)_RID Drechsler, M. (DE) Garamus, V. M. (DE) Willumeit-Römer, R. (DE) Zou, A. (CN)
Source Title	Colloids and Surfaces B-Biointerfaces. - : Elsevier - ISSN 0927-7765 Roč. 140, 1 April (2016), s. 74-82
Number of pages	9 s.
Language	eng - English
Country	NL - Netherlands
Keywords	baicalin ; liposomes ; folate receptor
Subject RIV	CF - Physical ; Theoretical Chemistry
R&D Projects	GC15-10527J GA ČR - Czech Science Foundation (CSF)
Institutional support	UMCH-V - RVO:61389013
UT WOS	000371445500009
EID SCOPUS	84951753939
DOI	10.1016/j.colsurfb.2015.11.018
Annotation	Bioavailability of baicalin (BAI), an example of traditional Chinese medicine, has been modified by loading into liposome. Several liposome systems of different composition i.e., lipid/cholesterol (L), long-circulating stealth liposome (L-PEG) and folate receptor (FR)-targeted liposome (L-FA) have been used as the drug carrier for BAI. The obtained liposomes were around 80 nm in diameter with proper zeta potentials about -25 mV and sufficient physical stability in 3 months. The entrapment efficiency and loading efficiency of BAI in the liposomes were 41.0-46.4% and 8.8-10.0%, respectively. The morphology details of BAI lipsosome systems i.e., formation of small unilamellar vesicles, have been determined by cryogenic transmission electron microscopy (cryo-TEM) and small angle X-ray scattering (SAXS). In vitro cytotoxicity of BAI liposomes against HeLa cells was evaluated by MTT assay. BAI loaded FR-targeted liposomes showed higher cytotoxicity and cellular uptake compared with non-targeted liposomes. The results suggested that L-FA-BAI could enhance anti-tumor efficiency and should be an effective FR-targeted carrier system for BAI delivery.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2017

Number of the records: 1