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A comparison of portal vein embolization with poly(2-hydroxyethylmethacrylate) and a histoacryl/lipiodol mixture in patients scheduled for extended right hepatectomy
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SYSNO ASEP 0455921 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A comparison of portal vein embolization with poly(2-hydroxyethylmethacrylate) and a histoacryl/lipiodol mixture in patients scheduled for extended right hepatectomy Author(s) Peregrin, J. H. (CZ)
Janoušek, R. (CZ)
Kautznerová, D. (CZ)
Oliverius, M. (CZ)
Sticová, E. (CZ)
Přádný, Martin (UMCH-V) RID
Michálek, Jiří (UMCH-V) RID, ORCIDSource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 64, č. 6 (2015), s. 841-848Number of pages 8 s. Language eng - English Country CZ - Czech Republic Keywords extended right hepatectomy ; portal vein embolization ; embolization-induced left liver lobe hypertrophy Subject RIV FH - Neurology R&D Projects GA13-00939S GA ČR - Czech Science Foundation (CSF) Institutional support UMCH-V - RVO:61389013 UT WOS 000367547900006 EID SCOPUS 84953272816 Annotation To determine whether PHEMA [poly(2-hydroxyethylmethacrylate)] is suitable for portal vein embolization in patients scheduled to right hepatectomy and whether it is as effective as the currently used agent (a histoacryl/lipiodol mixture). Two groups of nine patients each scheduled for extended right hepatectomy for primary or secondary hepatic tumor, had right portal vein embolization in an effort to induce future liver remnant (FLR) hypertrophy. One group had embolization with PHEMA, the other one with the histoacryl/lipiodol mixture. In all patients, embolization was performed using the right retrograde transhepatic access. Embolization was technically successful in all 18 patients, with no complication related to the embolization agent. Eight patients of either group developed FLR hypertrophy allowing extended right hepatectomy. Likewise, one patient in each group had recanalization of a portal vein branch. Histology showed that both embolization agents reach the periphery of portal vein branches, with PHEMA penetrating somewhat deeper into the periphery. PHEMA has been shown to be an agent suitable for embolization in the portal venous system comparable with existing embolization agent (histoacryl/lipiodol mixture). Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2016 Electronic address http://www.biomed.cas.cz/physiolres/2015/6_15.htm
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