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High-frequency oscillations and seizure activity and in the human anterior nucleus of the thalamus
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SYSNO ASEP 0455709 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title High-frequency oscillations and seizure activity and in the human anterior nucleus of the thalamus Author(s) Rektor, I. (CZ)
Doležalová, I. (CZ)
Chrastina, J. (CZ)
Jurák, Pavel (UPT-D) RID, ORCID, SAI
Halámek, Josef (UPT-D) RID, ORCID, SAI
Brázdil, M. (CZ)Number of authors 6 Source Title Epilepsia. - : Wiley - ISSN 0013-9580
Roč. 56, S1 (2015), s. 29-30Number of pages 2 s. Publication form Online - E Action International Epilepsy Congress /31./ Event date 05.09.2015-09.09.2015 VEvent location Istanbul Country TR - Turkey Event type WRD Language eng - English Country US - United States Keywords high-frequency oscillations ; anterior nucleus of the thalamus Subject RIV FS - Medical Facilities ; Equipment Institutional support UPT-D - RVO:68081731 Annotation Deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) has recently been introduced into therapy for refractory epilepsy. The role played by the ANT in human epileptic seizures and the mechanisms leading to the anti-seizure effects of ANT-DBS have not yet been fully elucidated. This is the first report of recording interictal and ictal activity in the human ANT. DBS electrodes were implanted in the ANT of six pharma- coresistent patients with temporal and extratemporal epilepsies who had not responded to vagus nerve stimulation. Interictal and ictal video-EEG was recorded via the DBS electrodes before the electrodes were internalized and a neurostimulation device was implanted. Interictal high frequency oscillations (HFO) of 80 to 240 Hz, in one case of 500 Hz, were recorded in four patients. Eight clinical seizures in four patients were recorded; a robust broad-band increase of power occurred in the early phases of all seizures. In two patients, the ictal changes preceded the clinical symptoms. No interictal epileptiform discharges were recorded; early epileptiform pattern preceding the clinical onset was recorded in one seizure.Based on our recordings of HFO, of early ictal EEG modifications, and of occurrences of ictal epileptiform pattern, we suggest that the ANT may participate actively in the network elaborating seizures in human epilepsies. Workplace Institute of Scientific Instruments Contact Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178 Year of Publishing 2016
Number of the records: 1