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Comparison of intraspinal and intrathecal implantation of induced pluripotent stem cell-derived neural precursors for the treatment of spinal cord injury in rats

SYSNO ASEP	0454661
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Comparison of intraspinal and intrathecal implantation of induced pluripotent stem cell-derived neural precursors for the treatment of spinal cord injury in rats
Author(s)	Amemori, Takashi (UEM-P)_RID Růžička, Jiří (UEM-P) Romanyuk, Nataliya (UEM-P)_RID Jhanwar-Uniyal, M. (US) Syková, Eva (UEM-P)_RID Jendelová, Pavla (UEM-P)_{RID, ORCID}
Number of authors	6
Source Title	Stem Cell Research & Therapy. - : BioMed Central Roč. 6, Dec (2015), s. 257
Number of pages	11 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	spinal cord injury ; human induced pluripotent stem cells ; cell therapy ; cell application route
Subject RIV	FH - Neurology
R&D Projects	LH12024 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UEM-P - RVO:68378041
UT WOS	000366894600001
EID SCOPUS	84951846358
DOI	10.1186/s13287-015-0255-2
Annotation	In the present study, we administered neural precursors derived from induced pluripotent stem cells (iPS-NPs) either intraspinally into the lesion center or intrathecally into the subarachnoid space of rats with a balloon-induced spinal cord compression lesion. Both treatments facilitated the functional locomotor recovery of rats with SCI. Intrathecal application of iPS-NPs has a positive therapeutic influence (resulting in locomotor improvement, moderate tissue sparing and axonal sprouting) on SCI through a paracrine mechanism that does not require the presence of cells in the tissue. However, the extended survival of intraspinally grafted cells in the spinal cord may promote long-term spinal cord tissue regeneration.
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2016

Number of the records: 1