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Targeted modulation of alternative splicing by TALE-directed chromatin editing
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SYSNO ASEP 0454301 Document Type A - Abstract R&D Document Type Není vybrán druh dokumentu Title Targeted modulation of alternative splicing by TALE-directed chromatin editing Author(s) Bieberstein, Nicole (UMG-J)
Staněk, David (UMG-J) RIDSource Title FEBS Journal - ISSN 1742-464X
Roč. 282, SI (2015), s. 210-210Number of pages 1 s. Action 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life Event date 04.07.2015 - 09.07.2015 VEvent location Berlín Country DE - Germany Event type WRD Language eng - English Country GB - United Kingdom Keywords histone methylation ; pre-mRNA splicing ; TALEN Subject RIV EB - Genetics ; Molecular Biology R&D Projects GBP305/12/G034 GA ČR - Czech Science Foundation (CSF) Institutional support UMG-J - RVO:68378050 UT WOS 000362570603176 Annotation To reveal how local chromatin modulates the splicing outcome we developed a new method based on Transcription Activator-Like Effector Nuclease (TALEN) technology. We replaced the nuclease domain with chromatin modifying domain and tested how TALE based targeting of histone methyltransferases and a demethylase influences splicing of the targeted exon. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2016
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