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Subdural infusion of dexamethasone inhibits leukomyelitis after acute spinal cord injury in a rat model
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SYSNO ASEP 0450830 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Subdural infusion of dexamethasone inhibits leukomyelitis after acute spinal cord injury in a rat model Author(s) Kwiecien, J. M. (CA)
Jarocz, B. (PL)
Machová-Urdzíková, Lucia (UEM-P) ORCID
Rola, R. (PL)
Dabrowski, W. (PL)Number of authors 5 Source Title Folia Neuropathologica - ISSN 1641-4640
Roč. 53, č. 1 (2015), s. 41-51Number of pages 11 s. Language eng - English Country PL - Poland Keywords spinal cord injury ; leukomyelitis ; macrophages ; subdural infusion ; dexamethasone Subject RIV FH - Neurology Institutional support UEM-P - RVO:68378041 UT WOS 000352466300006 EID SCOPUS 84925797560 DOI 10.5114/fn.2015.49973 Annotation Trauma in spinal cord injury often results in massive damage to the white matter and in damage to myelin that results in a severe phagocyte-rich infiltration apparently directed at removing immunologically toxic myelin debris. In the epidural balloon crush injury to the rat cranial thoracic spinal cord, the dorsal column was crushed, which at one week post-op resulted in its obliteration by a severe infiltration by a virtually pure population of macrophages that internalized all damaged myelin. A week-long subdural infusion of dexamethasone, a stable synthetic corticosteroid, resulted in remarkable inhibition of the macrophage infiltration of the crush cavity and in the lack of removal of myelin debris by phagocytosis. In this study we demonstrated that spinal cord injury results in a severe inflammatory response directed at massively damaged myelin, and we inhibited this response with a subdural infusion of a powerful anti-inflammatory drug, dexamethasone. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2016
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