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Expression and cellular localization of hepcidin mRNA and protein in normal rat brain
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SYSNO ASEP 0450356 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Expression and cellular localization of hepcidin mRNA and protein in normal rat brain Author(s) Raha-Chowdhury, R. (US)
Raha, A.A. (US)
Forostyak, Serhiy (UEM-P) RID, ORCID
Zhao, J.W. (US)
Stott, S.R.W. (US)
Bomford, A. (US)Number of authors 6 Source Title BMC Neuroscience. - : BioMed Central - ISSN 1471-2202
Roč. 16, APR 21 (2015), s. 24Number of pages 13 s. Language eng - English Country GB - United Kingdom Keywords hepcidin ; ferroportin ; defensin ; inflammatory cytokines ; brain iron homeostasis ; blood brain barrier ; pericytes ; sub-ventricular zone ; neurogenesis Subject RIV FH - Neurology Institutional support UEM-P - RVO:68378041 UT WOS 000353442700001 EID SCOPUS 84928569217 DOI 10.1186/s12868-015-0161-7 Annotation Hepcidin is a peptide hormone belonging to the defensin family of cationic antimicrobial molecule that has an essential role in systemic iron homeostasis. However, not all hepcidin in the brain is transcribed in situ and may originate in part outside the brain. The properties of hepcidin as a cationic peptide hormone are reflected in the finding of hepcidin in the walls of blood vessels and in pericytes and glia, cells that may be involved in transporting the peptide into brain interstitium Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2016
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