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Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease
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SYSNO ASEP 0449679 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease Author(s) Lake, A.D. (US)
Novák, Petr (BC-A) RID, ORCID
Shipkova, P. (US)
Aranibar, N. (US)
Robertson, D.G. (US)
Reily, M.D. (US)
Lehman-McKeeman, L.D. (US)
Vaillancourt, R.R. (US)
Cherrington, N.J. (US)Source Title Amino Acids. - : Springer - ISSN 0939-4451
Roč. 47, č. 3 (2015), s. 603-615Number of pages 13 s. Language eng - English Country AT - Austria Keywords Branched chain amino acid ; nonalcoholic fatty liver disease ; nonalcoholic steatohepatitis ; metabolomics and transcriptomics Subject RIV CE - Biochemistry Institutional support BC-A - RVO:60077344 UT WOS 000349390700015 DOI 10.1007/s00726-014-1894-9 Annotation Nonalcoholic fatty liver disease (NAFLD) is a globally widespread disease of increasing clinical significance. The pathological progression of the disease from simple steatosis to nonalcoholic steatohepatitis (NASH) has been well defined, however, the contribution of altered branched chain amino acid metabolomic profiles to the progression of NAFLD is not known. The three BCAAs: leucine, isoleucine and valine are known to mediate activation of several important hepatic metabolic signaling pathways ranging from insulin signaling to glucose regulation. The purpose of this study is to profile changes in hepatic BCAA metabolite levels with transcriptomic changes in the progression of human NAFLD to discover novel mechanisms of disease progression. Metabolomic and transcriptomic data sets representing the spectrum of human NAFLD (normal, steatosis, NASH fatty, and NASH not fatty livers) were utilized for this study. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2016
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