Biocompatible succinic acid-based polyesters for potential biomedical applications: fungal biofilm inhibition and mesenchymal stem cell growth

Jäger, Eliezer; Donato, R. K.; Perchacz, Magdalena; Jäger, Alessandro; Surman, František; Höcherl, Anita; Konefal, Rafal; Donato, K. Z.; Venturini, Cristina Garcia; Bergamo, V. Z.; Schrekker, H. S.; Fuentefria, A. M.; Raucci, M. G.; Ambrosio, L.; Štěpánek, Petr

doi:https://dx.doi.org/10.1039/C5RA15858C

Number of the records: 1

Biocompatible succinic acid-based polyesters for potential biomedical applications: fungal biofilm inhibition and mesenchymal stem cell growth

1.

SYSNO ASEP	0448644
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Biocompatible succinic acid-based polyesters for potential biomedical applications: fungal biofilm inhibition and mesenchymal stem cell growth
Author(s)	Jäger, Eliezer (UMCH-V)_{ORCID, RID} Donato, R. K. (BR) Perchacz, Magdalena (UMCH-V)_RID Jäger, Alessandro (UMCH-V)_{RID, ORCID} Surman, František (UMCH-V) Höcherl, Anita (UMCH-V)_RID Konefal, Rafal (UMCH-V)_{RID, ORCID} Donato, K. Z. (BR) Venturini, Cristina Garcia (UMCH-V) Bergamo, V. Z. (BR) Schrekker, H. S. (BR) Fuentefria, A. M. (BR) Raucci, M. G. (IT) Ambrosio, L. (IT) Štěpánek, Petr (UMCH-V)_{RID, ORCID}
Source Title	RSC Advances. - : Royal Society of Chemistry Roč. 5, č. 104 (2015), s. 85756-85766
Number of pages	11 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	polyesters ; coating of medical devices ; fungal biofilm inhibition
Subject RIV	EE - Microbiology, Virology
R&D Projects	7F14009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	FR-TI4/625 GA MPO - Ministry of Industry and Trade (MPO)
Institutional support	UMCH-V - RVO:61389013
UT WOS	000363179900071
EID SCOPUS	84944789828
DOI	10.1039/C5RA15858C
Annotation	Herein, we present the intrinsic property of well-known polyesters [poly(alkene succinates)], as Candida albicans and Candida tropicalis biofilm inhibitors with potential to substantially reduce the incidence of device-associated infections in, e.g., indwelling catheters and sutures. These new biopolymer applications, either for manufacturing or coating medical devices, present innovative features such as: simple and cheap preparation, easy scaling-up, good mechanical and thermal resistance properties, and antibiofilm ability without any specific surface functionalization or antimicrobial agent encapsulation. Furthermore, the polyesters are shown to be highly biocompatible, promote human mesenchymal stem cell (hMSC) attachment and proliferation, inducing morphological changes, which are dependent on the polymer structural characteristics, making them promising candidates for materials in specialized medical devices and in the tissue engineering field.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2016

Number of the records: 1