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Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines
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SYSNO ASEP 0448089 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines Author(s) Chen, Y. (CN)
Angelova, A. (FR)
Angelov, Borislav (UMCH-V) RID
Drechsler, M. (DE)
Garamus, V. M. (DE)
Willumeit-Römer, R. (DE)
Zou, A. (CN)Source Title Journal of Materials Chemistry B - ISSN 2050-750X
Roč. 3, č. 39 (2015), s. 7734-7744Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords SAXS ; soft matter ; nanoparticles Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects GC15-10527J GA ČR - Czech Science Foundation (CSF) Institutional support UMCH-V - RVO:61389013 UT WOS 000362350600011 EID SCOPUS 84942852277 DOI 10.1039/C5TB01193K Annotation Multidrug delivery devices are designed to take advantage of the synergistic effects of anticancer agents in combination therapies. Here we report novel liquid crystalline self-assembled nanocarriers enhancing the activity of the phytochemical anticancer agent baicalin (BAI) in combination with Brucea javanica oil (BJO), which ensures safe formulations for clinical applications. Small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) evidenced the multicompartment, sponge-type nano-organization of the blank and multidrug-loaded liquid crystalline carriers. Physico-chemical stability of the sponge nanoparticles was achieved through PEGylation of the lipid membranes, which make up the drug nanocarriers. The proposed green nanotechnology for nanocarrier preparation by supramolecular self-assembly provided a multidrug encapsulation efficiency as high as 75%. The apoptosis study with the human lung carcinoma cell line A549 demonstrated improved efficacy of the multidrug delivery nanocarriers in comparison to the single-drug reservoirs. The obtained results evidenced the synergistic anticancer apoptotic effects of the multidrug-loaded nanosponge carriers and suggested the opportunity for in vivo translation towards the treatment of lung, gastrointestinal, and ovarian cancers. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2016
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