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The utility of three-dimensional optical projection tomography in nerve injection injury imaging
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SYSNO ASEP 0446968 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The utility of three-dimensional optical projection tomography in nerve injection injury imaging Author(s) Cvetko, E. (SI)
Čapek, Martin (FGU-C) RID, ORCID
Damjanovska, M. (SI)
Reina, M. A. (ES)
Eržen, I. (SI)
Stopar-Pintarič, T. (SI)Source Title Anaesthesia - ISSN 0003-2409
Roč. 70, č. 8 (2015), s. 939-947Number of pages 9 s. Language eng - English Country US - United States Keywords optical projection tomography ; 3D nerve visualization ; nerve disruption Subject RIV EA - Cell Biology R&D Projects GA13-12412S GA ČR - Czech Science Foundation (CSF) LH13028 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 000357731200008 EID SCOPUS 84936845897 DOI 10.1111/anae.13066 Annotation The objective of this study was to evaluate the ability of optical projection tomography to discern the nerve microarchitecture and injection injury in three dimensions. Five piglets were studied, whose median and lingual nerves were unilaterally injected post mortem with preset volumes of local anaesthetic, excised and subsequently made transparent with benzyl alcohol benzyl benzoate. Images were captured in three dimensions. The same contralateral nerves were used as controls. Using optical projection tomography, we observed differences between the internal organisation of the median and the lingual nerves, which potentially explain the variations in their susceptibility to injury. This was demonstrated in three dimensions as a disruption to the fascicles in the lingual nerve, and their displacement in the median nerve. This new technology offers potential for studying nerve microarchitecture topography and its tolerance to injection injury Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2016
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