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A New Analogue of Locked Cyclohexane Nucleic Acids
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SYSNO ASEP 0446581 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A New Analogue of Locked Cyclohexane Nucleic Acids Author(s) Šála, Michal (UOCHB-X) RID, ORCID
Dejmek, Milan (UOCHB-X) RID, ORCID
Procházková, Eliška (UOCHB-X) RID, ORCID
Hřebabecký, Hubert (UOCHB-X) RID, ORCID
Rybáček, Jiří (UOCHB-X) RID, ORCID
Dračínský, Martin (UOCHB-X) RID, ORCID
Novák, Pavel (UOCHB-X)
Rosenbergová, Šárka (UOCHB-X) RID
Rosenberg, Ivan (UOCHB-X) RID, ORCID
Nencka, Radim (UOCHB-X) RID, ORCIDNumber of authors 10 Source Title Synthesis. - : Georg Thieme Verlag - ISSN 0039-7881
Roč. 47, č. 17 (2015), s. 2654-2662Number of pages 9 s. Language eng - English Country DE - Germany Keywords nucleosides ; bicyclic compounds ; oligonucleotides ; carbocycles ; medicinal chemistry Subject RIV CC - Organic Chemistry R&D Projects GPP207/12/P625 GA ČR - Czech Science Foundation (CSF) GA13-26526S GA ČR - Czech Science Foundation (CSF) Institutional support UOCHB-X - RVO:61388963 UT WOS 000360095900020 EID SCOPUS 84939567683 DOI 10.1055/s-0034-1380744 Annotation We report on a new analogue of locked cyclohexane nucleic acids that contains an adenine nucleobase at an alternative position and which resembles homo-DNA. The crucial locked carbocyclic nucleoside monomer was prepared with high enantioselectivity and was subsequently incorporated into a pair of modified oligonucleotides that were subjected to hybridization studies. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2016
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