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A Difference in Fatty Acid Composition of Isocaloric High-Fat Diets Alters Metabolic Flexibility in Male C57BL/6JOlaHsd Mice

SYSNO ASEP	0446423
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	A Difference in Fatty Acid Composition of Isocaloric High-Fat Diets Alters Metabolic Flexibility in Male C57BL/6JOlaHsd Mice
Author(s)	Duivenvoorde, L. P. M. (NL) van Schothorst, E. M. (NL) Swarts, H. M. (NL) Kuda, Ondřej (FGU-C)_{RID, ORCID, SAI} Steenbergh, E. (NL) Termeulen, S. (NL) Kopecký, Jan (FGU-C)_{RID, ORCID} Keijer, J. (NL)
Source Title	PLoS ONE. - : Public Library of Science - ISSN 1932-6203 Roč. 10, č. 6 (2015), e0128515
Number of pages	19 s.
Language	eng - English
Country	US - United States
Keywords	PUFA ; satureted fatty acids ; high fat diet ; metabolic flexibility ; indirect calorimetry
Subject RIV	FB - Endocrinology, Diabetology, Metabolism, Nutrition
R&D Projects	7E10059 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	FGU-C - RVO:67985823
UT WOS	000356835800016
DOI	10.1371/journal.pone.0128515
Annotation	The aim of this study was to determine the effect of high-fat diets with different fatty acid compositions, but similar n6/n3 ratio (with either predominantly PUFAs (HFpu diet) or predominantly SFAs (HFs diet)), on metabolic flexibility. We found that the HFs diet, compared to the HFpu diet, increased mean adipocyte size, liver damage, and ectopic lipid storage in liver and muscle; although, we did not find differences in body weight, total adiposity, adipose tissue health, serum adipokines, whole body energy balance, or circadian rhythm between HFs and HFpu mice. HFs mice were, furthermore, less flexible in their response to both fasting- re-feeding and OxR, while glucose tolerance was indistinguishable. To conclude, the HFs versus the HFpu diet increased ectopic fat storage, liver damage, and mean adipocyte size and reduced metabolic flexibility in male mice. This study underscores the physiological relevance of indirect calorimetry-based challenge tests
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2016

Number of the records: 1