Number of the records: 1
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
- 1.
SYSNO ASEP 0446227 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead Author(s) Goodson, W.H. (US)
Vondráček, Jan (BFU-R) RID, ORCIDNumber of authors 147 Source Title Carcinogenesis. - : Oxford University Press - ISSN 0143-3334
Roč. 36, JUN 2015 (2015), s. 254-296Number of pages 43 s. Publication form Print - P Language eng - English Country GB - United Kingdom Keywords BREAST-CANCER CELLS ; ESTROGEN-RECEPTOR-ALPHA ; EPITHELIAL-MESENCHYMAL TRANSITION Subject RIV BO - Biophysics R&D Projects GA13-07711S GA ČR - Czech Science Foundation (CSF) UT WOS 000357048100013 DOI 10.1093/carcin/bgv039 Annotation Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer. This risk may be overlooked by current regulatory practices and needs to be vigorously investigated.Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2016
Number of the records: 1