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Fate of the Molar Dental Lamina in the Monophyodont Mouse
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SYSNO ASEP 0445769 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Fate of the Molar Dental Lamina in the Monophyodont Mouse Author(s) Dosedělová, Hana (UZFG-Y)
Dumková, J. (CZ)
Lesot, H. (FR)
Glocová, K. (CZ)
Kunová, M. (CZ)
Tucker, A. S. (GB)
Veselá, Iva (UZFG-Y)
Krejčí, P. (CZ)
Tichý, F. (CZ)
Hampl, A. (CZ)
Buchtová, Marcela (UZFG-Y) RID, ORCIDSource Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 10, č. 5 (2015), e0127543Number of pages 22 s. Publication form Online - E Language eng - English Country US - United States Keywords epithelial stem cells ; tooth replacement Subject RIV EA - Cell Biology R&D Projects GB14-37368G GA ČR - Czech Science Foundation (CSF) GP14-29273P GA ČR - Czech Science Foundation (CSF) Institutional support UZFG-Y - RVO:67985904 UT WOS 000355183900107 DOI 10.1371/journal.pone.0127543 Annotation The successional dental lamina (SDL) plays an essential role in the development of replacement teeth in diphyodont and polyphyodont animals. A morphologically similar structure, the rudimental successional dental lamina (RSDL), has been described in monophyodont (only one tooth generation) lizards on the lingual side of the developing functional tooth. This rudimentary lamina regresses, which has been proposed to play a role in preventing the formation of future generations of teeth. A similar rudimentary lingual structure has been reported associated with the first molar in the monophyodont mouse, and we show that this structure is common to all murine molars. Intriguingly, a lingual lamina is also observed on the non-replacing molars of other diphyodont mammals (pig and hedgehog), initially appearing very similar to the successional dental lamina on the replacing teeth. We have analyzed the morphological as well as ultrastructural changes that occur during the development and loss of this molar lamina in the mouse, from its initiation at late embryonic stages to its disappearance at postnatal stages. We show that loss appears to be driven by a reduction in cell proliferation, down-regulation of the progenitor marker Sox2, with only a small number of cells undergoing programmed cell death. The lingual lamina was associated with the dental stalk, a short epithelial connection between the tooth germ and the oral epithelium. The dental stalk remained in contact with the oral epithelium throughout tooth development up to eruption when connective tissue and numerous capillaries progressively invaded the dental stalk. The buccal side of the dental stalk underwent keratinisation and became part of the gingival epithelium, while most of the lingual cells underwent programmed cell death and the tissue directly above the erupting tooth was shed into the oral cavity. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2016
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