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Mitochondria in Cancer: Why Mitochondria Are a Good Target for Cancer Therapy
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SYSNO ASEP 0444484 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mitochondria in Cancer: Why Mitochondria Are a Good Target for Cancer Therapy Author(s) Dong, L.F. (AU)
Neužil, Jiří (BTO-N) RIDSource Title Progress in Molecular Biology and Translational Science - ISSN 1877-1173
Roč. 2014, č. 127 (2014), s. 211-227Number of pages 18 s. Language eng - English Country US - United States Keywords ALPHA-TOCOPHERYL SUCCINATE ; RESPIRATORY COMPLEX-II ; DNA MUTATIONS Subject RIV EB - Genetics ; Molecular Biology Institutional support BTO-N - RVO:86652036 UT WOS 000341461400008 DOI 10.1016/B978-0-12-394625-6.00008-8 Annotation Cancer can be characterized as a state of multifaceted cellular deregulation including control of proliferation and bioenergetics. The latter involves in particular mitochondria, the site of the generation of ATP, essential for the proper cellular function (including proliferation). Mitochondria also contain a variety of proteins that are necessary for the induction/promotion, as well as for the prevention of cell death. Therefore, mitochondria are pivotal in deciding the fate of a cell. In cancer, mitochondria are dysfunctional, which was observed as early as in the 1930s by Otto Warburg. Due to the central role of mitochondria, these organelles, endowed with its own DNA, are a focus of research as possible "culprits" for the malignancy of cancer cells (or at least contributing to this phenotype) and, importantly, as emerging targets for anticancer therapy. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2016
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