Number of the records: 1

Knockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila – A role for dFoxO?

SYSNO ASEP	0444024
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Knockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila – A role for dFoxO?
Author(s)	Bednářová, Andrea (BC-A)_{RID, ORCID} Kodrík, Dalibor (BC-A)_{RID, ORCID} Krishnan, N. (US)
Number of authors	3
Source Title	Comparative Biochemistry and Physiology Part C. - : Elsevier - ISSN 1532-0456 Roč. 171, May 01 (2015), s. 8-14
Number of pages	7 s.
Language	eng - English
Country	US - United States
Keywords	adipokinetic hormone ; Drosophila ; hydrogen peroxide
Subject RIV	ED - Physiology
R&D Projects	GA14-07172S GA ČR - Czech Science Foundation (CSF)
	LH14047 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	BC-A - RVO:60077344
UT WOS	000354343400002
EID SCOPUS	84925783892
DOI	10.1016/j.cbpc.2015.03.006
Annotation	Signaling pathways of insect adipokinetic hormones (AKHs) in anti-oxidative response are unclear. Exposure to hydrogen peroxide (HP) revealed that AKH-RNAi flies showed significantly higher mortality than AKH-oex or control lines. AKH-RNAi flies had significantly less dFoxO transcript and translated protein compared to control and AKH-oex flies in un-challenged condition as well as when challenged with HP. Sestrin – a major antioxidant defense protein and one of the targets of dFoxO – was also significantly down-regulated in AKH-RNAi flies (both unchallenged and challenged with HP) compared to control flies and flies with over-expressed AKH. These findings imply that dFoxO may act downstream of AKH as a transcription factor to mediate response to OS in D. melanogaster.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2016
Electronic address	http://www.sciencedirect.com/science/article/pii/S1532045615000265

Number of the records: 1