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Collagen-lactoferrin fibrillar coatings enhance osteoblast proliferation and differentiation

SYSNO ASEP	0443426
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Collagen-lactoferrin fibrillar coatings enhance osteoblast proliferation and differentiation
Author(s)	Vandrovcová, Marta (FGU-C)_{RID, ORCID} Douglas, T.E.L. (BE) Heinemann, S. (DE) Scharnweber, D. (DE) Dubruel, P. (BE) Bačáková, Lucie (FGU-C)_{RID, ORCID}
Source Title	Journal of Biomedical Materials Research. Part A. - : Wiley - ISSN 1549-3296 Roč. 103, č. 2 (2015), s. 525-533
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	lactoferin ; collagen ; bone cells
Subject RIV	EI - Biotechnology ; Bionics
R&D Projects	GBP108/12/G108 GA ČR - Czech Science Foundation (CSF)
Institutional support	FGU-C - RVO:67985823
UT WOS	000349101700010
EID SCOPUS	84924324334
DOI	10.1002/jbm.a.35199
Annotation	The main aim of the study was to evaluate the effects of the aECM on the adhesion, growth and osteogenic differentiation of human osteoblast-like Saos-2 cells. The cell adhesion was evaluated by the cell number and spreading area on day 1 after seeding. The cell proliferation was estimated from the cell number on day 3, and the osteogenic differentiation was assessed by the expression of collagen type I, osteocalcin (OC) and alkaline phosphatase (ALP) on day 7 after seeding. This is a first study concerning lactoferin as a component of a biomaterial coating and the influence of such coating on cell behavior
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2016

Number of the records: 1