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Colloidally stable surface-modified iron oxide nanoparticles: preparation, characterization and anti-tumor activity
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SYSNO ASEP 0442140 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Colloidally stable surface-modified iron oxide nanoparticles: preparation, characterization and anti-tumor activity Author(s) Macková, Hana (UMCH-V) RID
Horák, Daniel (UMCH-V) RID, ORCID
Donchenko, G. V. (UA)
Andriyaka, V. I. (UA)
Palyvoda, O. M. (UA)
Chernishov, V. I. (UA)
Chekhun, V. F. (UA)
Todor, I. N. (UA)
Kuzmenko, O. I. (UA)Source Title Journal of Magnetism and Magnetic Materials. - : Elsevier - ISSN 0304-8853
Roč. 380, 15 April (2015), s. 125-131Number of pages 7 s. Action International Conference on the Scientific and Clinical Applications of Magnetic Carriers /10./ Event date 10.06.2014-14.06.2014 VEvent location Dresden Country DE - Germany Event type WRD Language eng - English Country NL - Netherlands Keywords iron oxide nanoparticle ; poly(N,N-dimethylacrylamide-co-acrylic acid) ; protein oxidation Subject RIV CD - Macromolecular Chemistry R&D Projects 7E12054 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LH14318 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMCH-V - RVO:61389013 UT WOS 000349360800021 EID SCOPUS 84922932921 DOI 10.1016/j.jmmm.2014.09.037 Annotation Maghemite (γ-Fe2O3) nanoparticles were obtained by co-precipitation of Fe(II) and Fe(III) chlorides and subsequent oxidation with sodium hypochlorite and coated with poly(N,N-dimethylacrylamide-co-acrylic acid) [P(DMAAm-AA)]. They were characterized by a range of methods including transmission electron microscopy (TEM), elemental analysis, dynamic light scattering (DLS) and zeta potential measurements. The effect of superparamagnetic P(DMAAm-AA)-γ-Fe2O3 nanoparticles on oxidation of blood lipids, glutathione and proteins in blood serum was detected using 2-thiobarbituric acid and the ThioGlo fluorophore. Finally, mice received magnetic nanoparticles administered per os and the antitumor activity of the particles was tested on Lewis lung carcinoma (LLC) in male mice line С57ВL/6 as an experimental in vivo metastatic tumor model; the tumor size was measured and the number of metastases in lungs was determined. Surface-modified γ-Fe2O3 nanoparticles showed higher antitumor and antimetastatic activities than commercial CuFe2O4 particles and the conventional antitumor agent cisplatin. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2015
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