Number of the records: 1

IB-MECA, an Adenosine A(3) Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice

SYSNO ASEP	0440789
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	IB-MECA, an Adenosine A(3) Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice
Author(s)	Hofer, Michal (BFU-R)_{RID, ORCID} Pospíšil, Milan (BFU-R) Dušek, L. (CZ) Hoferová, Zuzana (BFU-R)_RID Komůrková, Denisa (BFU-R)_{RID, ORCID}
Number of authors	5
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 61, č. 6 (2012), s. 649-654
Number of pages	6 s.
Publication form	Print - P
Language	eng - English
Country	CZ - Czech Republic
Keywords	Mouse ; IB-MECA ; Adenosine A(3) receptor agonist
Subject RIV	BO - Biophysics
R&D Projects	GA305/08/0158 GA ČR - Czech Science Foundation (CSF)
	GAP303/11/0128 GA ČR - Czech Science Foundation (CSF)
Institutional support	BFU-R - RVO:68081707
UT WOS	000314138600011
Annotation	In our previous studies, IB-MECA, an adenosine A(3) receptor agonist, was found to stimulate proliferation of hematopoietic progenitor and precursor cells in mice. This property of IB-MECA was considered to be responsible for its ability to support regeneration of suppressed hematopoiesis after irradiation with sublethal doses of y-rays when the drug was given in a post-irradiation treatment regimen. This study was aimed at assessing the ability of IB-MECA to influence a 30-day survival of lethally irradiated mice. In a series of experiments, IB-MECA was administered following various lethal radiation doses in various numbers of drug doses and various administration routes. Though in some of these experiments a moderate increase in 30-day survival was observed in IB-MECA-treated mice, the differences in comparison with the controls were not significantly different.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2015

Number of the records: 1