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Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines

SYSNO ASEP	0439957
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines
Author(s)	Šebo, Peter (MBU-M)_{RID, ORCID} Osička, Radim (MBU-M)_{RID, ORCID} Mašín, Jiří (MBU-M)_{RID, ORCID}
Number of authors	3
Source Title	Expert Review of Vaccines - ISSN 1476-0584 Roč. 13, č. 10 (2014), s. 1215-1227
Number of pages	13 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	adenylate cyclase toxin ; antigen delivery ; Bordetella pertussis
Subject RIV	EE - Microbiology, Virology
R&D Projects	GA13-14547S GA ČR - Czech Science Foundation (CSF)
	GAP302/11/0580 GA ČR - Czech Science Foundation (CSF)
	GAP302/12/0460 GA ČR - Czech Science Foundation (CSF)
Institutional support	MBU-M - RVO:61388971
UT WOS	000342073300008
Annotation	The adenylate cyclase toxin-hemolysin (ACT, AC-Hly or CyaA) is a key virulence factor of Bordetella pertussis. It targets bactericidal activities of phagocytes, such as oxidative burst and complement- or antibody-mediated opsonophagocytic killing of bacteria. Through cAMP signaling, CyaA also skews TLR-triggered maturation of dendritic cells, inhibiting proinflammatory IL-12 and TNF- secretion and enhancing IL-10 production and Treg expansion, likely hampering induction of adaptive immune responses to Bordetella infections. Non-enzymatic CyaA toxoid is a potent protective antigen and adjuvant that boosts immunogenicity of co-administered B. pertussis antigens and improves potency of acellular pertussis (aP) vaccines in mice. This makes CyaA a prime antigen candidate for inclusion into a next generation of aP vaccines. Moreover, recombinant CyaA toxoids were recently shown to be safe in humans in frame of Phase I clinical evaluation of a CyaA-based immunotherapeutic vaccine that induces Th1-polarized CD8(+) cytotoxic T-lymphocyte responses targeting cervical tumors.
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2015

Number of the records: 1