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A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats

SYSNO ASEP	0439460
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats
Author(s)	Mareš, Pavel (FGU-C)_{RID, ORCID}
Source Title	Journal of Neural Transmission. - : Springer - ISSN 0300-9564 Roč. 121, č. 11 (2014), s. 1329-1336
Number of pages	8 s.
Language	eng - English
Country	AT - Austria
Keywords	adenosine receptors ; epileptic afterdischarges ; cerebral cortex ; ontogeny ; rat
Subject RIV	FH - Neurology
R&D Projects	LH11015 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	FGU-C - RVO:67985823
UT WOS	000344353700002
EID SCOPUS	84901522884
DOI	10.1007/s00702-014-1234-y
Annotation	Endo- as well as exogenous adenosine exhibits anticonvulsant action. Participation of individual types of adenosine receptors was studied in present experiments in immature rats. Cortical epileptic afterdischarges were used as a model in rat pups 12, 18 and 25 days old. CCPA, an agonist of A1 adenosine receptors, decreased markedly duration of afterdischarges whereas DPCPX, an antagonist of A1 receptors, exhibited strong proconvulsant action. Action of either drug was best expressed in 12-day-old rats and it decreased with age. Drugs influencing A2A adenosine receptors (agonist CGS21680 and antagonist ZM241385) did not exhibit systematic effects in our model. Motor phenomena accompanying cortical stimulation or epileptic afterdischarge were never influenced by any of the four drugs studied. A1 adenosine receptors are important in the model of cortical seizures, especially in the youngest group studied
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2015

Number of the records: 1