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Excess NF-kB induces ectopic odontogenesis in embryonic incisor epithelium
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SYSNO ASEP 0438519 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Excess NF-kB induces ectopic odontogenesis in embryonic incisor epithelium Author(s) Blackburn, J. (GB)
Kawasaki, K. (GB)
Porntaveetus, T. (GB)
Kawasaki, M. (GB)
Otsuka-Tanaka, Y. (GB)
Miake, Y. (JP)
Ota, M. S. (JP)
Watanabe, M. (JP)
Hishinuma, M. (JP)
Nomoto, T. (JP)
Oommen, S. (GB)
Ghafoor, S. (GB)
Harada, F. (GB)
Nozawa-Inoue, K. (GB)
Maeda, T. (JP)
Peterková, Renata (UEM-P) RID
Lesot, H. (FR)
Inoue, J. (JP)
Akiyama, T. (JP)
Schmidt-Ulrich, R. (DE)
Liu, B. (US)
Hu, Y. (US)
Page, A. (ES)
Ramírez, Á. (ES)
Sharpe, P. T. (GB)
Ohazama, A. (GB)Source Title Journal of Dental Research. - : Sage - ISSN 0022-0345
Roč. 94, č. 1 (2015), s. 121-128Number of pages 8 s. Language eng - English Country US - United States Keywords incisor ; tooth development Subject RIV EA - Cell Biology R&D Projects GB14-37368G GA ČR - Czech Science Foundation (CSF) Institutional support UEM-P - RVO:68378041 UT WOS 000346506200016 EID SCOPUS 84919464755 DOI 10.1177/0022034514556707 Annotation Nuclear factor kappa B (NF-κB) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-κB signaling during development results in hypohidrotic ectodermal dysplasia. The roles of NF-κB signaling in tooth development, however, are not fully understood. We examined mice overexpressing IKKβ, an essential component of the NF-κB pathway, under keratin 5 promoter (K5-Ikkβ). K5-Ikkβ mice showed supernumerary incisors whose formation was accompanied by up-regulation of canonical Wnt signaling. Apoptosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikkβ mice. The supernumerary incisors in K5-Ikkβ mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise. Excess NF-κB activity thus induces an ectopic odontogenesis program that is usually suppressed under physiological conditions. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2016
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