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Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs

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    SYSNO ASEP0438496
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleAdenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs
    Author(s) Hejnová, L. (CZ)
    Hahnová, K. (CZ)
    Kočková, Radka (FGU-C)
    Svatůňková, Jarmila (FGU-C)
    Sedmera, David (FGU-C) RID, ORCID, SAI
    Novotný, J. (CZ)
    Source TitleBioMed Research International. - : Hindawi - ISSN 2314-6133
    Roč. 2014, č. 2014 (2014), s. 463123
    Number of pages6 s.
    Languageeng - English
    CountryUS - United States
    Keywordsembryonic heart ; embryotoxicity ; adenylyl cyclase ; G protein ; beta-blocking agents
    Subject RIVFA - Cardiovascular Diseases incl. Cardiotharic Surgery
    R&D ProjectsGAP302/11/1308 GA ČR - Czech Science Foundation (CSF)
    Institutional supportFGU-C - RVO:67985823
    UT WOS000338534700001
    EID SCOPUS84904158936
    DOI10.1155/2014/463123
    AnnotationThe adenylyl cyclase (AC) signaling system plays a crucial role in the regulation of cardiac contractility. Here we analyzed the key components of myocardial AC signaling in the developing chick embryo and assessed the impact of selected beta-blocking agents on this system. Application of metoprolol and carvedilol, two commonly used beta-blockers, at embryonic day (ED) 8 significantly downregulated (by about 40%) expression levels of AC5, the dominant cardiac AC isoform, and the amount of Gs alpha protein at ED9. Activity of AC stimulated by forskolin was also significantly reduced under these conditions. Interestingly, when administered at ED4, these drugs did not produce such profound changes in the myocardial AC signaling system, except for markedly increased expression of Gi alpha protein. These data indicate that beta-blocking agents can strongly derange AC signaling during the first half of embryonic heart development
    WorkplaceInstitute of Physiology
    ContactLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Year of Publishing2015
Number of the records: 1  

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