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Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP

SYSNO ASEP	0438420
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP
Author(s)	Zavala-Tecuapetla, Cecília (FGU-C) Kubová, Hana (FGU-C)_{RID, ORCID} Otáhal, Jakub (FGU-C)_{RID, ORCID, SAI} Tsenov, Grygoriy (FGU-C)_{RID, ORCID} Mareš, Pavel (FGU-C)_{RID, ORCID}
Source Title	Pharmacological Reports. - : Springer - ISSN 1734-1140 Roč. 66, č. 5 (2014), s. 927-930
Number of pages	4 s.
Language	eng - English
Country	PL - Poland
Keywords	epileptic afterdischarge ; hippocampus ; rat ; ontogeny ; metabotropic glutamate receptor 5
Subject RIV	FH - Neurology
R&D Projects	GA305/09/0846 GA ČR - Czech Science Foundation (CSF)
	GBP304/12/G069 GA ČR - Czech Science Foundation (CSF)
Institutional support	FGU-C - RVO:67985823
UT WOS	000341061600030
DOI	10.1016/j.pharep.2014.02.018
Annotation	Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured.MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals.Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2015

Number of the records: 1