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Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP
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SYSNO ASEP 0438420 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP Author(s) Zavala-Tecuapetla, Cecília (FGU-C)
Kubová, Hana (FGU-C) RID, ORCID
Otáhal, Jakub (FGU-C) RID, ORCID, SAI
Tsenov, Grygoriy (FGU-C) RID, ORCID
Mareš, Pavel (FGU-C) RID, ORCIDSource Title Pharmacological Reports. - : Springer - ISSN 1734-1140
Roč. 66, č. 5 (2014), s. 927-930Number of pages 4 s. Language eng - English Country PL - Poland Keywords epileptic afterdischarge ; hippocampus ; rat ; ontogeny ; metabotropic glutamate receptor 5 Subject RIV FH - Neurology R&D Projects GA305/09/0846 GA ČR - Czech Science Foundation (CSF) GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000341061600030 DOI https://doi.org/10.1016/j.pharep.2014.02.018 Annotation Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured.MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals.Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2015
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