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Polymer therapeutics for treatment of viral infections such as Ebola - how to teach new tricks to an old dog? A hypothesis

SYSNO ASEP	0437495
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	Polymer therapeutics for treatment of viral infections such as Ebola - how to teach new tricks to an old dog? A hypothesis
Author(s)	Hrubý, Martin (UMCH-V)_{RID, ORCID}
Source Title	Military Medical Science Letters. - : Univerzita obrany - ISSN 0372-7025 Roč. 83, č. 4 (2014), s. 178-182
Number of pages	5 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	Ebola virus ; cathepsin ; polymer
Subject RIV	EE - Microbiology, Virology
R&D Projects	7F14009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA13-08336S GA ČR - Czech Science Foundation (CSF)
Institutional support	UMCH-V - RVO:61389013
Annotation	Polymer drug delivery systems were during last few decades proven to be efficient potential therapeutics for cancer treatment, especilly for the treatment of solid tumors, where they may take advantage of the Enhanced Permeability and Retention (EPR) effect for tumor-specific passive accumulation. Controlled release of anticancer drugs in cancer cells may be triggered by. e.g., cathepsin B activation after endocytosis. Endosomal proteases, especially cathepsins B and L, are known to be one of the key factors influencing some viral infections. For instance Ebola virus requires partial proteolysis of its surface glycoprotein for efficient endosome escape within its life cycle. We hypothesize that polymeric cathepsin B and L inhibitors may utilize advantages of polymer delivery systems for more effective treatment of viral infections with cathepsin inhibitors reducing systemic toxicity and increasing efficacy by targeted delivery of these inhibitors.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2015
Electronic address	http://mmsl.cz/viCMS/soubory/pdf/MMSL_2014_4_5_WWW.pdf

Number of the records: 1