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Electron hopping through proteins
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SYSNO ASEP 0437102 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Electron hopping through proteins Author(s) Warren, J. J. (US)
Ener, M. E. (US)
Vlček, Antonín (UFCH-W) RID, ORCID
Winkler, J. R. (US)
Gray, H. B. (US)Source Title Coordination Chemistry Reviews. - : Elsevier - ISSN 0010-8545
Roč. 256, 21-22 (2012), s. 2478-2487Number of pages 10 s. Language eng - English Country NL - Netherlands Keywords electron transfer ; multistep tunneling ; hopping maps Subject RIV CG - Electrochemistry R&D Projects ME10124 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UFCH-W - RVO:61388955 UT WOS 000309895800008 EID SCOPUS 84866390958 DOI 10.1016/j.ccr.2012.03.032 Annotation Biological redox machines require efficient transfer of electrons and holes for function. Reactions involving multiple tunneling steps, termed "hopping," often promote charge separation within and between proteins that is essential for energy storage and conversion. Here we show how semiclassical electron transfer theory can be extended to include hopping reactions: graphical representations (called hopping maps) of the dependence of calculated two-step reaction rate constants on driving force are employed to account for flow in a rhenium-labeled azurin mutant as well as in two structurally characterized redox enzymes, DNA photolyase and MauG. Analysis of the 35 angstrom radical propagation in ribonucleotide reductases using hopping maps shows that all tyrosines and tryptophans on the radical pathway likely are involved in function. We suggest that hopping maps can facilitate the design and construction of artificial photosynthetic systems for the production of fuels and other chemicals. (C) 2012 Elsevier B.V. All rights reserved. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2015
Number of the records: 1