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Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell
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SYSNO ASEP 0436140 Document Type P - Patent R&D Document Type Patent or other outcome protected by special legislation Title Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell Author(s) Šebo, Peter (MBU-M) RID, ORCID
Leclerc, C. (FR)
Osičková, Adriana (MBU-M) RID, ORCID
Fayolle, C. (FR)
Mašín, Jiří (MBU-M) RID, ORCID
Krůšek, Jan (FGU-C) RID, ORCID
Osička, Radim (MBU-M) RID, ORCID
Basler, Marek (MBU-M)Year of issue 2014 Possible third party use of the result A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence Royalty requested A - Poskytovatel licence požaduje licenční poplatek Patent no. or utility model no. or industrial design no. EP2233569 Date of the patent acceptance 25.06.2014 Name of the patent owner Institut Pasteur - Mikrobiologický ústav AV ČR, v. v. i. - Fyziologický ústav AV ČR,v. v. i. Code of the issuer name EPO_1 - European Patent Office Munich, The Hague, Berlin, Vienna, Brusselshttp://www.epo.org/ Current use B - Patent je využíván na základě uzavřené licenční smlouvy mezi vlastníkem a uživatelem Language eng - English Keywords Bordetella pertusis ; adenylate cyclase protein Subject RIV EE - Microbiology, Virology R&D Projects GA310/08/0447 GA ČR - Czech Science Foundation (CSF) 2B06161 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support MBU-M - RVO:61388971 ; FGU-C - RVO:67985823 Annotation The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host. The invention is more particularly directed to polypeptides derived from an adenylate cyclase protein (CyaA) either under the form of a toxin or of a toxoid, which are mutant polypeptides. Said mutant polypeptides are capable of retaining the binding activity of native CyaA to a target cell and preferably of also retaining the translocating activity of native CyaA through its N-terminal domain into target cells and furthermore have a pore-forming activity which is reduced or suppressed as compared to that of the native CyaA toxin. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2015 Electronic address http://worldwide.espacenet.com/publicationDetails/biblio?CC=EP&NR=2233569B1&KC=B1&FT=D&ND=4&date=20140625&DB=worldwide.espacenet.com&locale=en_EP
Number of the records: 1