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Beneficial effect of human induced pluripotent stem cell-derived neural precursors in spinal cord injury repair
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SYSNO ASEP 0435646 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Beneficial effect of human induced pluripotent stem cell-derived neural precursors in spinal cord injury repair Author(s) Romanyuk, Nataliya (UEM-P) RID
Amemori, Takashi (UEM-P) RID
Turnovcová, Karolína (UEM-P) ORCID
Procházka, Pavel (UEM-P) RID
Onteniente, B. (FR)
Syková, Eva (UEM-P) RID
Jendelová, Pavla (UEM-P) RID, ORCIDSource Title Cell Transplantation. - : Sage - ISSN 0963-6897
Roč. 24, č. 9 (2015), s. 1781-1797Number of pages 17 s. Language eng - English Country US - United States Keywords human induced pluripotent stem cells ; neural precursors ; spinal cord injury Subject RIV FH - Neurology R&D Projects LH12024 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA13-00939S GA ČR - Czech Science Foundation (CSF) GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LO1309 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEM-P - RVO:68378041 UT WOS 000361419700009 EID SCOPUS 84940763193 DOI 10.3727/096368914X684042 Annotation Neural precursors differentiated from induced pluripotent stem cells were grafted into rat spinal cord injury. They survived well and slowly mature into different neuronal phenotypes (GABAergic, serotonergic and motoneurons). In addition, they produced growth factors, stimulating neuronal sprouting. As a result, animals with spinal cord injury significantly improved their motor function. Rats were able to support their body weight and perform stepping, so they scored well in tests requiring movement coordination, such as beam walking or rotarod. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2016
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