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Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants
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SYSNO ASEP 0435644 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants Author(s) Rössner ml., Pavel (UEM-P) RID, ORCID
Rössnerová, Andrea (UEM-P) RID
Beskid, Olena (UEM-P)
Tabashidze, Nana (UEM-P)
Líbalová, Helena (UEM-P) RID
Uhlířová, Kateřina (UEM-P)
Topinka, Jan (UEM-P) RID, ORCID
Šrám, Radim (UEM-P) RIDNumber of authors 8 Source Title Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. - : Elsevier - ISSN 0027-5107
763-764, MAY-JUN 2014 (2014), s. 28-38Number of pages 11 s. Language eng - English Country NL - Netherlands Keywords benzo[a]pyrene ; chromosome aberrations ; double-strand DNA breaks Subject RIV DN - Health Impact of the Environment Quality R&D Projects GAP503/11/0084 GA ČR - Czech Science Foundation (CSF) Institutional support UEM-P - RVO:68378041 UT WOS 000336694800004 EID SCOPUS 84897944027 DOI 10.1016/j.mrfmmm.2014.03.006 Annotation The cells were treated for 24 h with B[a]P (1 μM, 10 μM, 25 μM) and EOMs (1 μg/ml, 10 μg/ml, 25 μg/ml). 25 μM of B[a]P and most of the tested doses of EOMs induced double strand breaks (DSBs) as indicated by H2AX phosphorylation. DNA damage was accompanied by induction of XRCC4 expression and an increased frequency of chromosomal aberrations. Translocations most frequently affected chromosome 7. We observed only a weak induction of Ku70/80 expression as well as ligation activity of nuclear extracts. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2015
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