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Frequent Chromatin Rearrangements in Myelodysplastic Syndromes - What Stands Behind?

SYSNO ASEP	0435477
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Frequent Chromatin Rearrangements in Myelodysplastic Syndromes - What Stands Behind?
Author(s)	Pagáčová, Eva (BFU-R)_ORCID Falk, Martin (BFU-R)_{RID, ORCID} Falková, Iva (BFU-R)_ORCID Lukášová, Emilie (BFU-R)_{RID, ORCID} Michalová, K. (CZ) Oltová, A. (CZ) Raška, I. (CZ) Kozubek, Stanislav (BFU-R)_RID
Number of authors	8
Source Title	Folia Biologica. - : Univerzita Karlova v Praze - ISSN 0015-5500 Roč. 60, č. 2014 (2014), s. 1-7
Number of pages	8 s.
Publication form	Print - P
Language	eng - English
Country	CZ - Czech Republic
Keywords	myelodysplastic syndromes ; chromosomal rearrangements ; chromosome 5 deletions
Subject RIV	BO - Biophysics
R&D Projects	GBP302/12/G157 GA ČR - Czech Science Foundation (CSF)
	EE2.3.30.0030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	BFU-R - RVO:68081707
UT WOS	000343275800001
Annotation	Myelodysplastic syndromes (MDS) represent a clinically and genetically heterogeneous group of clonal haematopoietic diseases characterized by a short survival and high rate of transformation to acute myeloid leukaemia (AML). In spite of this variability, MDS is associated with typical recurrent non-random cytogenetic defects. Chromosomal abnormalities are detected in the malignant bone-marrow cells of approximately 40-80 % of patients with primary or secondary MDS. The most frequent chromosomal rearrangements involve chromosomes 5, 7 and 8. MDS often shows presence of unbalanced chromosomal changes, especially large deletions [del(5), del(7q), del(12p), del(18q), del(20q)] or losses of whole chromosomes (7 and Y). The most typical cytogenetic abnormality is a partial or complete deletion of 5q- that occurs in roughly 30 % of all MDS cases either as the sole abnormality or in combination with other aberrations as a part of frequently complex karyotypes. The mechanisms responsible for the formation of MDS-associated recurrent trans-locations and complex karyotypes are unknown.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2015

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