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Comprehensive interrogation of the cellular response to fluorescent, detonation and functionalized nanodiamonds
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SYSNO ASEP 0435341 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Comprehensive interrogation of the cellular response to fluorescent, detonation and functionalized nanodiamonds Author(s) Moore, L. (US)
Grobárová, Valeria (MBU-M)
Shen, H. (US)
Man, H. B. (US)
Mičová, Júlia (UOCHB-X)
Ledvina, Miroslav (UOCHB-X) RID
Štursa, Jan (UJF-V) RID, ORCID
Nesladek, M. (CZ)
Fišerová, Anna (MBU-M) RID
Ho, D. (US)Number of authors 10 Source Title Nanoscale. - : Royal Society of Chemistry - ISSN 2040-3364
Roč. 6, č. 20 (2014), s. 11712-11721Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords nitrogen-vacancy centers ; biomedical aplications ; nanodiamonds Subject RIV CF - Physical ; Theoretical Chemistry Subject RIV - cooperation Institute of Microbiology - Microbiology, Virology R&D Projects LM2011019 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UOCHB-X - RVO:61388963 ; MBU-M - RVO:61388971 ; UJF-V - RVO:61389005 UT WOS 000343000800018 EID SCOPUS 84907483739 DOI 10.1039/c4nr02570a Annotation Nanodiamonds (NDs) are versatile nanoparticles that are currently being investigated for a variety of applications in drug delivery, biomedical imaging and nanoscale sensing. Although initial studies indicate that these small gems are biocompatible, there is a great deal of variability in synthesis methods and surface functionalization that has yet to be evaluated. Here we present a comprehensive analysis of the cellular compatibility of an array of nanodiamond subtypes and surface functionalization strategies. These results demonstrate that NDs are well tolerated by multiple cell types at both functional and gene expression levels. In addition, ND-mediated delivery of daunorubicin is less toxic to multiple cell types than treatment with daunorubicin alone, thus demonstrating the ability of the ND agent to improve drug tolerance and decrease therapeutic toxicity. Overall, the results here indicate that ND biocompatibility serves as a promising foundation for continued preclinical investigation. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2015
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