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Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters
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SYSNO ASEP 0435165 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters Author(s) Hofer, Michal (BFU-R) RID, ORCID
Pospíšil, Milan (BFU-R)
Dušek, L. (CZ)
Hoferová, Zuzana (BFU-R) RID
Komůrková, Denisa (BFU-R) RID, ORCIDNumber of authors 5 Source Title Purinergic Signalling - ISSN 1573-9538
Roč. 10, č. 3 (2014), s. 509-514Number of pages 6 s. Publication form Print - P Language eng - English Country NL - Netherlands Keywords Adenosine A(3) receptor ; Adenosine A(3) receptor knockout mice ; Hematopoiesis Subject RIV BO - Biophysics R&D Projects GAP303/11/0128 GA ČR - Czech Science Foundation (CSF) Institutional support BFU-R - RVO:68081707 UT WOS 000341772500010 DOI 10.1007/s11302-014-9412-9 Annotation The role of the adenosine A(3) receptor in hematopoiesis was studied using adenosine A(3) receptor knockout (A(3)AR KO) mice. Hematological parameters of peripheral blood and femoral bone marrow of irradiated and untreated A(3)AR KO mice and their wild-type (WT) counterparts were investigated. Irradiation of the mice served as a defined hematopoiesis-damaging means enabling us to evaluate contingent differences in the pattern of experimentally induced hematopoietic suppression between the A(3)AR KO mice and WT mice. Defects were observed in the counts and/or functional parameters of blood cells in the A(3)AR KO mice. These defects include statistically significantly lower values of blood neutrophil and monocyte counts, as well as those of mean erythrocyte volume, mean erythrocyte hemoglobin, blood platelet counts, mean platelet volume, and plateletcrit, and can be considered to bear evidence of the lack of a positive role played by the adenosine A(3) receptor in the hematopoietic system. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2015
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