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Simulation-based design of a microfabricated pneumatic electrospray nebulizer
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SYSNO ASEP 0434464 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Simulation-based design of a microfabricated pneumatic electrospray nebulizer Author(s) Járvás, G. (CZ)
Grym, Jakub (UIACH-O)
Foret, František (UIACH-O) RID, ORCID
Guttman, A. (HU)Number of authors 4 Source Title Electrophoresis. - : Wiley - ISSN 0173-0835
Roč. 36, č. 3 (2015), s. 386-392Number of pages 7 s. Publication form Print - P Language eng - English Country DE - Germany Keywords CFD ; microfabrication ; modeling ; electrospray ; nebulizer Subject RIV CB - Analytical Chemistry, Separation R&D Projects GBP206/12/G014 GA ČR - Czech Science Foundation (CSF) Institutional support UIACH-O - RVO:68081715 UT WOS 000349220500003 DOI 10.1002/elps.201400387 Annotation A microfabricated pneumatic electrospray nebulizer has been developed and evaluated using computer simulations and experimental measurements of the mass spectrometry signals. The microdevice under development is designed for electrospray mass spectrometry interfacing without the need to fabricate an electrospray needle and can be used as a disposable or an integral part of a reusable system. The design of the chip layout was supported by computational fluid dynamics simulations. The tested microdevices were fabricated in glass using conventional photolithography, followed by wet chemical etching and thermal bonding. The performance of the microfabricated nebulizer was evaluated by means of time-of-flight mass spectrometry with a peptide mixture. It was demonstrated that the nebulizer, operating at supersonic speed of the nebulizing gas, produced very stable nanospray (900 nl/min) as documented by less than 0.1 % (standard error) fluctuation in total mass spectrometric signal intensity. Workplace Institute of Analytical Chemistry Contact Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234 Year of Publishing 2015
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