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Influence of surface-modified maghemite nanoparticles on in vitro survival of human stem cells
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SYSNO ASEP 0433566 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Influence of surface-modified maghemite nanoparticles on in vitro survival of human stem cells Author(s) Babič, Michal (UMCH-V) RID, ORCID
Horák, Daniel (UMCH-V) RID, ORCID
Lukash, L. L. (UA)
Ruban, T. A. (UA)
Kolomiets, Y. N. (UA)
Shpylova, S. P. (UA)
Grypych, O. A. (UA)Source Title Beilstein Journal of Nanotechnology. - : Beilstein - Institut zur Foerderung der Chemischen Wissenschaften - ISSN 2190-4286
Roč. 5, 8 October (2014), s. 1732-1737Number of pages 6 s. Language eng - English Country DE - Germany Keywords maghemite ; magnetic ; MTT assay Subject RIV CD - Macromolecular Chemistry R&D Projects EE2.3.30.0029 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LH14318 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMCH-V - RVO:61389013 UT WOS 000344115100001 DOI 10.3762/bjnano.5.183 Annotation Surface-modified maghemite (γ-Fe2O3) nanoparticles were obtained by using a conventional precipitation method and coated with D-mannose and poly(N,N-dimethylacrylamide). Both the initial and the modified particles were characterized by transmission electron microscopy and dynamic light scattering with regard to morphology, particle size and polydispersity. In vitro survival of human stem cells was then investigated by using the methyl thiazolyl tetrazolium (MTT) assay, which showed that D-mannose- and poly(N,N-dimethylacrylamide)-coated γ-Fe2O3 particles exhibit much lower level of cytotoxicity than the non-coated γ-Fe2O3. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2015
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