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Xenobiotic administration affects biotransformations of thyroid hormones in the rat
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SYSNO ASEP 0432139 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Xenobiotic administration affects biotransformations of thyroid hormones in the rat Author(s) Pavelka, Stanislav (FGU-C) RID
Soukup, Tomáš (FGU-C) RID
Tribulová, N. (SK)Source Title Zborník príspevkov z medzinárodného vedeckého sympózia“Priemyslná toxikológia 2014“. - Bratislava : Slovenská technická univerzita, 2014 - ISBN 978-80-227-4181-1 Pages s. 109-115 Number of pages 7 s. Publication form Print - P Action Priemyselná toxikológia 2014 Event date 18.06.2014-20.06.2014 VEvent location Svit, Vysoké Tatry Country SK - Slovakia Event type EUR Language eng - English Country SK - Slovakia Keywords enzyme ; thyroid hormone ; xenobiotic Subject RIV ED - Physiology R&D Projects 7AMB14SK123 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 Annotation With the use of our newly developed radiometric enzyme assays for the determination of enzyme activities of iodothyronine deiodinases (IDs) of the types D1, D2 and D3, and adapted radiometric assays for quantification of iodothyronine sulfotransferases (ST) and uridine 5‘-diphospho glucuronyltransferase (UDP-GT), we proved thyrotoxic effects of excessive exogenous bromide and perchlorate ions. Profound changes in enzyme activities were also determined in rats treated with an antidepressant drug fluoxetine (Fluox), especially in case of IDs in their pituitary and cerebellum Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2015
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