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Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma
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SYSNO ASEP 0432084 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma Author(s) Olejár, Tomáš (FGU-C) RID
Větvička, D. (CZ)
Zadinová, M. (CZ)
Poučková, P. (CZ)
Kukal, J. (CZ)
Ježek, Petr (FGU-C) RID, ORCID
Matěj, R. (CZ)Source Title Anticancer Research. - : International Institute of Anticancer Research - ISSN 0250-7005
Roč. 34, č. 7 (2014), s. 3511-3515Number of pages 5 s. Language eng - English Country GR - Greece Keywords PAR2 ; melanoma ; metastasis ; murine model Subject RIV EA - Cell Biology R&D Projects GAP302/10/0346 GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000338780300036 EID SCOPUS 84906310625 Annotation Differences of metastatic spread of normal proteinase-activated receptor 2 (Par2+/+) melanoma B16 in Par2−/− (knock-out) animals compared with C57Bl6 mice were investigated. Excised primary tumors were in average larger in Par2−/− mice (360 mm3 vs. 221 mm3 in C57Bl6/J). Distant spontaneous metastases developed in only 3 of 9 of Par2−/− mice in comparison to 6 of 9 controls. Host Par2 melanoma model contributes to the limitation of local cancer progression in one area, while on the other hand is important for enhancing distant metastatic spread Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2015
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