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Age-Related Differences in NMDA Receptor Subunits of Prenatally Methamphetamine-Exposed Male Rats
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SYSNO ASEP 0430525 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Age-Related Differences in NMDA Receptor Subunits of Prenatally Methamphetamine-Exposed Male Rats Author(s) Vrajová, M. (CZ)
Schutová, B. (CZ)
Klaschka, Jan (UIVT-O) RID, SAI, ORCID
Štěpánková, H. (CZ)
Řípová, D. (CZ)
Šlamberová, R. (CZ)Source Title Neurochemical Research. - : Springer - ISSN 0364-3190
Roč. 39, č. 11 (2014), s. 2040-2046Number of pages 7 s. Language eng - English Country US - United States Keywords methamphetamine ; in-utero ; NMDA receptor subunits ; hippocampus Subject RIV FH - Neurology Institutional support UIVT-O - RVO:67985807 UT WOS 000343293000003 EID SCOPUS 84910107229 DOI 10.1007/s11064-014-1381-4 Annotation There is accumulating evidence that methamphetamine (MA) is a widely abused drug popular among pregnant women. MA exposure is associated with changes in the function of neurotransmitter systems, namely the dopaminergic, serotonergic and glutamatergic systems. Since N-methyl-d-aspartate receptors (NMDA) are affected by MA-induced glutamate release, we assessed the expression of NMDAR subunits (NR1, NR2A, and NR2B) and postsynaptic density protein 95 (PSD-95), which is connected with NMDAR. We measured the expression of these proteins in adolescent (30 days old) and adult (60 days old) rat males exposed to MA during the entire prenatal period and compared them with the same parameters in age matched saline-exposed rats. There was a significant increase in the NR1 and NR2B subunits in the hippocampus of adult males, but not in adolescent males. We identified a significant change in adult MA-induced rats when compared to adult controls for NR2A and NR2B, while in adolescent MA rats this change was close to the boundary of significance. In summary, our study suggests that prenatal MA exposure is connected with changes in NMDAR subunit expression in adult rats but not in adolescent rats. Workplace Institute of Computer Science Contact Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Year of Publishing 2015
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