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Electrochemical analysis of DNA using switchable redox moieties
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SYSNO ASEP 0429318 Document Type C - Proceedings Paper (int. conf.) R&D Document Type The record was not marked in the RIV Title Electrochemical analysis of DNA using switchable redox moieties Author(s) Fojta, Miroslav (BFU-R) RID, ORCID
Daňhel, Aleš (BFU-R) RID, ORCID
Horáková Brázdilová, Petra (BFU-R)
Plucnara, Medard (BFU-R) ORCID
Pivoňková, Hana (BFU-R) ORCID
Havran, Luděk (BFU-R) RID, ORCID
Vidláková, Pavlína (BFU-R)
Raindlová, Veronika (UOCHB-X) RID
Balintová, Jana (UOCHB-X) RID
Macíčková-Cahová, Hana (UOCHB-X) RID, ORCID
Hocek, Michal (UOCHB-X) RID, ORCIDNumber of authors 11 Source Title Chemistry of Nucleic Acid Components. 16th Symposium. - Praha : Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2014 / Hocek M. - ISBN 978-80-86241-50-0 Pages s. 264-266 Number of pages 3 s. Publication form Print - P Action Symposium on Chemistry of Nucleic Acid Components /16./ Event date 08.06.2014-13.06.2014 VEvent location Český Krumlov Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords DNA ; electrochemical analysis ; switchable redox moieties Subject RIV CC - Organic Chemistry Subject RIV - cooperation Institute of Biophysics - Biophysics R&D Projects GBP206/12/G151 GA ČR - Czech Science Foundation (CSF) Institutional support UOCHB-X - RVO:61388963 ; BFU-R - RVO:68081707 Annotation Labelling of DNA with electrochemically active moieties proved to be a convenient way to the development of electrochemical techniques for the sequence-specific DNA sensing. Through combinations of various labels differing in redox potentials, independent redox coding of different DNA sequences or individual nucleobases can be attained. Applications possibilities of electrochemistry in analysis of modified DNAs are further extended by facile monitoring of chemical conversion of reactive groups on DNA during post-labelling with ultimate redox labels. In addition, controlled in situ electrochemical conversions of specific intrinsic and extrinsic DNA components can be utilized to switch their electrochemical signals and improve signal resolution. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2015
Number of the records: 1