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Contribution of Ca2+-Dependent Cl- Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing

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    SYSNO ASEP0428048
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleContribution of Ca2+-Dependent Cl- Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing
    Author(s) Líšková, Silvia (FGU-C)
    Petrová, M. (SK)
    Karen, Petr (FGU-C)
    Behuliak, Michal (FGU-C) RID
    Zicha, Josef (FGU-C) RID
    Source TitleBioMed Research International - ISSN 2314-6133
    Roč. 2014, č. 2014 (2014), s. 289361
    Number of pages9 s.
    Languageeng - English
    CountryUS - United States
    Keywordscalcium-dependent chloride channels ; endothelium-derived contracting factor ; ageing
    Subject RIVFA - Cardiovascular Diseases incl. Cardiotharic Surgery
    R&D ProjectsGAP304/12/0259 GA ČR - Czech Science Foundation (CSF)
    Institutional supportFGU-C - RVO:67985823
    UT WOS000332565500001
    EID SCOPUS84897882006
    DOI10.1155/2014/289361
    AnnotationThe activation of calcium-dependent chloride channels during norepinephrine-induced contraction of vascular smooth muscle was suggested to depolarize cell membrane and to increase calcium entry. Hypertension and ageing are associated with altered calcium handling including possible activation of calcium-dependent chloride channels. Our study was aimed to determine calcium -dependent chloride channels contribution to norepinephrine-induced contraction during hypertension and ageing. We have found that contribution of calcium -dependent chloride channels to norepinephrine-induced contraction diminished with age, hypertension development, and/or NO synthesis inhibition
    WorkplaceInstitute of Physiology
    ContactLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Year of Publishing2015