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Contribution of Ca2+-Dependent Cl- Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing

SYSNO ASEP	0428048
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Contribution of Ca2+-Dependent Cl- Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing
Author(s)	Líšková, Silvia (FGU-C) Petrová, M. (SK) Karen, Petr (FGU-C) Behuliak, Michal (FGU-C)_{RID, ORCID} Zicha, Josef (FGU-C)_{RID, ORCID, SAI}
Source Title	BioMed Research International. - : Hindawi - ISSN 2314-6133 Roč. 2014, č. 2014 (2014), s. 289361
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	calcium-dependent chloride channels ; endothelium-derived contracting factor ; ageing
Subject RIV	FA - Cardiovascular Diseases incl. Cardiotharic Surgery
R&D Projects	GAP304/12/0259 GA ČR - Czech Science Foundation (CSF)
Institutional support	FGU-C - RVO:67985823
UT WOS	000332565500001
EID SCOPUS	84897882006
DOI	10.1155/2014/289361
Annotation	The activation of calcium-dependent chloride channels during norepinephrine-induced contraction of vascular smooth muscle was suggested to depolarize cell membrane and to increase calcium entry. Hypertension and ageing are associated with altered calcium handling including possible activation of calcium-dependent chloride channels. Our study was aimed to determine calcium -dependent chloride channels contribution to norepinephrine-induced contraction during hypertension and ageing. We have found that contribution of calcium -dependent chloride channels to norepinephrine-induced contraction diminished with age, hypertension development, and/or NO synthesis inhibition
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2015

Number of the records: 1