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beta-Arrestin Interacts with the Beta/Gamma Subunits of Trimeric G-Proteins and Dishevelled in the Wnt/Ca2+ Pathway in Xenopus Gastrulation
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SYSNO ASEP 0427975 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title beta-Arrestin Interacts with the Beta/Gamma Subunits of Trimeric G-Proteins and Dishevelled in the Wnt/Ca2+ Pathway in Xenopus Gastrulation Author(s) Seitz, K. (DE)
Dursch, V. (DE)
Harnoš, J. (CZ)
Bryja, Vítězslav (BFU-R) RID, ORCID
Gentzel, M. (DE)
Schambony, A. (DE)Number of authors 6 Source Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 9, č. 1 (2014)Number of pages 11 s. Publication form Print - P Language eng - English Country US - United States Keywords CONVERGENT EXTENSION MOVEMENTS ; WNT SIGNALING PATHWAYS ; WNT/BETA-CATENIN Subject RIV BO - Biophysics R&D Projects GC204/09/J030 GA ČR - Czech Science Foundation (CSF) Institutional support BFU-R - RVO:68081707 UT WOS 000330570000107 DOI 10.1371/journal.pone.0087132 Annotation beta-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and beta-Catenin independent signaling cascades including the Wnt/Planar Cell Polarity and the Wnt/Ca2+ cascades. Wnt/Planar Cell Polarity and Wnt/Ca2+ pathways share common effector proteins, including the Wnt ligand, Frizzled receptors and Dishevelled, with each other and with additional branches of Wnt signaling. Along with the aforementioned proteins, beta-Arrestin has been identified as an essential effector protein in the Wnt/beta-Catenin and the Wnt/Planar Cell Polarity pathway. Our results demonstrate that beta-Arrestin is required in the Wnt/Ca2+ signaling cascade upstream of Protein Kinase C (PKC) and Ca2+/Calmodulin-dependent Protein Kinase II (CamKII). We have further characterized the role of beta-Arrestin in this branch of non-canonical Wnt signaling by knock-down and rescue experiments in Xenopus embryo explants and analyzed protein-protein interactions in 293T cells. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2015
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