DNA Condensing Effects and Sequence Selectivity of DNA Binding of Antitumor Noncovalent Polynuclear Platinum Complexes

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SYSNO ASEP	0427974
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	DNA Condensing Effects and Sequence Selectivity of DNA Binding of Antitumor Noncovalent Polynuclear Platinum Complexes
Author(s)	Malina, Jaroslav (BFU-R)_ORCID Farrell, N. P. (US) Brabec, Viktor (BFU-R)_{RID, ORCID}
Number of authors	3
Source Title	Inorganic Chemistry. - : American Chemical Society - ISSN 0020-1669 Roč. 53, č. 3 (2014), s. 1662-1671
Number of pages	10 s.
Publication form	Print - P
Language	eng - English
Country	US - United States
Keywords	INTERSTRAND CROSS-LINKS ; LASER-LIGHT SCATTERING ; CALF THYMUS DNA
Subject RIV	BO - Biophysics
R&D Projects	GA13-08273S GA ČR - Czech Science Foundation (CSF)
	LH13096 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	BFU-R - RVO:68081707
UT WOS	000330812700048
DOI	10.1021/ic402796k
Annotation	The noncovalent analogues of antitumor polynuclear platinum complexes represent a structurally discrete class of platinum drugs. Their chemical and biological properties differ significantly from those of most platinum chemotherapeutics, which bind to DNA in a covalent manner by formation of Pt-DNA adducts. In spite of the fact that these noncovalent polynuclear platinum complexes contain no leaving groups, they have been shown to bind to DNA with high affinity.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2015

Number of the records: 1