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Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size
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SYSNO ASEP 0425219 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size Author(s) Shubhra, Q. T. H. (HU)
Kardos, A. F. (HU)
Feczkó, T. (HU)
Macková, Hana (UMCH-V) RID
Horák, Daniel (UMCH-V) RID, ORCID
Tóth, J. (HU)
Dósa, G. (HU)
Gyenis, J. (HU)Source Title Journal of Microencapsulation - ISSN 0265-2048
Roč. 31, č. 2 (2014), s. 147-155Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords albumin ; encapsulation ; PLGA (poly d,l-lactic-co-glycolic acid Subject RIV JB - Sensors, Measurment, Regulation R&D Projects KAN401220801 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) Institutional support UMCH-V - RVO:61389013 UT WOS 000334739200005 EID SCOPUS 84894148393 DOI 10.3109/02652048.2013.814729 Annotation PLGA (poly d,l-lactic-co-glycolic acid) nanoparticles (NPs) encapsulating magnetite nanoparticles (MNPs) along with a model drug human serum albumin (HSA) were prepared by double emulsion solvent evaporation method. This Part I will focus on size and size distribution of prepared NPs, whereas encapsulation efficiency will be discussed in Part II. It was found that mean hydrodynamic particle size was influenced by five important process variables. To explore their effects, a five-factorial, three-level experimental design and statistical analysis were carried out using STATISTICA® software. Effect of process variables on the mean size of nanoparticles was investigated and finally conditions to minimize size of NPs were proposed. GAMS™/MINOS software was used for optimization. The mean hydrodynamic size of nanoparticles ranged from 115 to 329 nm depending on the process conditions. Smallest possible mean particle size can be achieved by using low polymer concentration and high dispersion energy (enough sonication time) along with small aqueous/organic volume ratio. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2014
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