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Biotransformation of Silybin and its Congeners
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SYSNO ASEP 0423434 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biotransformation of Silybin and its Congeners Author(s) Křen, Vladimír (MBU-M) RID, ORCID
Marhol, Petr (MBU-M) RID
Purchartová, Kateřina (MBU-M) RID
Gabrielová, E. (CZ)
Modrianský, M. (CZ)Source Title Current Drug Metabolism. - : Bentham Science Publishers - ISSN 1389-2002
Roč. 14, č. 10 (2013), s. 1009-1021Number of pages 13 s. Language eng - English Country AE - United Arab Emirates Keywords Biotransformation ; cytochrome P450 ; diastereoisomers Subject RIV CE - Biochemistry R&D Projects GAP301/11/0662 GA ČR - Czech Science Foundation (CSF) LD11051 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support MBU-M - RVO:61388971 UT WOS 000329033900001 Annotation Silybin and its congeners belong to a group of flavonolignans with strong biological activities. These compounds are potentially applicable in human medicine, e.g. due to their cytoprotective activity. As a part of herbal preparations available on the open market, they face the risk of potential negative drug-drug interactions. This review aims to evaluate current knowledge on the metabolism of these compounds by biotransformation enzymes, interactions with other drugs, their pharmacokinetics, and bioavailability. While silybin and its derivatives interact with cytochrome P450s, only metabolism of silybin by cytochrome P450 2C8 poses a risk of adverse effects. The main biotransformation route of silybin and derivatives was identified as conjugation, which is stereospecific in case of silybin. Studies of the metabolism, pharmacokinetics, potentional drug - drug interactions and increasing bioavailability of these flavonolignans play an important facet of possible therapeutical use of these compounds. The goal of our review is to aid future developments in the area of silybin research Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2014 Electronic address http://www.ncbi.nlm.nih.gov/pubmed/24261705
Number of the records: 1