Sox4 is a key oncogenic target in C/EBP alpha mutant acute myeloid leukemia

Zhang, H.; Alberich-Jorda, Meritxell; Amabile, G.; Yang, H.; Staber, P.B.; DiRuscio, A.; Welner, R.S.; Ebralidze, A.; Zhang, J.; Levantini, E.; Lefebvre, V.; Valk, P.J.; Delwel, R.; Hoogenkamp, M.; Nerlov, C.; Cammenga, J.; Saez, B.; Scadden, D.T.; Bonifer, C.; Ye, M.; Tenen, D.G.

doi:https://dx.doi.org/10.1016/j.ccr.2013.09.018

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Sox4 is a key oncogenic target in C/EBP alpha mutant acute myeloid leukemia

1.

SYSNO ASEP	0422959
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Sox4 is a key oncogenic target in C/EBP alpha mutant acute myeloid leukemia
Author(s)	Zhang, H. (US) Alberich-Jorda, Meritxell (UMG-J)_RID Amabile, G. (US) Yang, H. (SG) Staber, P.B. (US) DiRuscio, A. (US) Welner, R.S. (US) Ebralidze, A. (US) Zhang, J. (US) Levantini, E. (US) Lefebvre, V. (US) Valk, P.J. (NL) Delwel, R. (NL) Hoogenkamp, M. (GB) Nerlov, C. (GB) Cammenga, J. (SE) Saez, B. (US) Scadden, D.T. (US) Bonifer, C. (GB) Ye, M. (US) Tenen, D.G. (US)
Source Title	Cancer Cell. - : Elsevier - ISSN 1535-6108 Roč. 24, č. 5 (2013), s. 575-588
Number of pages	14 s.
Publication form	Print - P
Language	eng - English
Country	US - United States
Keywords	Sox4 ; C/EBP alpha ; acute myeloid leukemia
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	LK21307 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UMG-J - RVO:68378050
UT WOS	000327005100006
DOI	10.1016/j.ccr.2013.09.018
Annotation	Mutation or epigenetic silencing of the transcription factor C/EBP alpha is observed in similar to 10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but downstream targets relevant for leukemogenesis are not known. Here, we identify Sox4 as a direct target of C/EBP alpha whereby its expression is inversely correlated with C/EBP alpha activity. Downregulation of Sox4 abrogated increased self-renewal of leukemic cells and restored their differentiation. Gene expression profiles of leukemia-initiating cells (LICs) from both Sox4 overexpression and murine C/EBP alpha mutant AML models clustered together but differed from other types of AML. Our data demonstrate that Sox4 overexpression resulting from C/EBP alpha inactivation contributes to the development of leukemia with a distinct LIC phenotype.
Workplace	Institute of Molecular Genetics
Contact	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Year of Publishing	2014

Number of the records: 1